With only weeks to live, Joe sets out to find his true lost love, make up for missed life experiences, and potentially spend his last days on the sleazy streets of New Orleans. Life quickly takes a turn for the absurd when he meets a misdirected crew of cast-offs that includes a religious cult escapee, a novice stripper, and an insane ventriloquist hitchhiker (played by Tenacious D's Kyle Glass). Life, and potentially death, takes on new meaning as Joe re-evaluates everything, and everyone, he has ever known.